检索范围:
排序: 展示方式:
Laser ablation of block copolymers with hydrogen-bonded azobenzene derivatives
Jintang Huang, Youju Huang, Si Wu
《化学科学与工程前沿(英文)》 2018年 第12卷 第3期 页码 450-456 doi: 10.1007/s11705-018-1735-6
Supramolecular assemblies (PS-b-P4VP(AzoR)) are fabricated by hydrogen-bonding azobenzene derivatives (AzoR) to poly(4-vinyl pyridine) blocks of polystyrene-block-poly(4-vinyl pyridine) (PS-b-P4VP). PS-b-P4VP(AzoR) forms phase separated nanostructures with a period of ~75–105 nm. A second length scale structure with a period of 2 µm is fabricated on phase separated PS-b-P4VP(AzoR) by laser interference ablation. Both the concentration and the substituent of AzoR in PS-b-P4VP(AzoR) affect the laser ablation process. The laser ablation threshold of PS-b-P4VP(AzoR) decreases as the concentration of AzoR increases. In PS-b-P4VP(AzoR) with different substituents (R= CN, H, and CH3), ablation thresholds follow the trend: PS-b-P4VP(AzoCN)<PS-b-P4VP(AzoCH3)<PS-b-P4VP(AzoH). This result indicates that the electron donor group (CH3) and the electron acceptor group (CN) can lower the ablation threshold of PS-b-P4VP(AzoR).
关键词: laser ablation block copolymers hydrogen-bond azobenzene derivatives supramolecular assembly
Advances in managing hepatocellular carcinoma
null
《医学前沿(英文)》 2014年 第8卷 第2期 页码 175-189 doi: 10.1007/s11684-014-0332-4
Multiple modalities for treatment of hepatocellular carcinoma are available, depending on tumor size and number. Surgical resection remains the gold standard, so long as the residual liver function reserve is sufficient. In patients with advanced cirrhosis, liver transplantation is the preferred option, as these patients may not have adequate hepatic reserve after resection. Salvage liver transplantation has also become an option for a select few patients who recur after surgical resection. Ablative techniques have been used for palliation as well as to either completely destroy the tumor, act as an adjunct to resection, or downstage the tumor to meet Milan criteria such that a patient may be a candidate for liver transplantation. Radiofrequency ablation, microwave ablation, chemoembolization, radioembolization, and irreversible electroporation have all been used in this capacity. Currently, sorafenib is the only US Food and Drug Administration-approved chemotherapeutic for hepatocellular carcinoma. The efficacy of sorafenib, in combination with other agents, transarterial chemoembolization, and surgical resection is currently being investigated. Sunitinib and brivanib, tyrosine kinase inhibitors, have failed as potential first- or second-line options for chemotherapy. Bevacizumab in combination with erlotinib is also currently being studied. Final analysis for ramucirumab and axitinib are pending. Tivantinib, a selective mesenchymal-epithelial transition factor (MET) inhibitor, is also undergoing clinical trials for efficacy in MET-high tumors. This review serves to emphasize the current and new technologies emerging in the treatment of hepatocellular carcinoma.
关键词: hepatocellular carcinoma radiofrequency ablation microwave ablation chemoembolization radioembolization sorafenib irreversible electroporation
Towards the optimization of management of hepatocellular carcinoma
Xi Feng, Madhava Pai, Malkhaz Mizandari, Tinatin Chikovani, Duncan Spalding, Long Jiao, Nagy Habib
《医学前沿(英文)》 2011年 第5卷 第3期 页码 271-276 doi: 10.1007/s11684-011-0148-4
关键词: management hepatocellular carcinoma (HCC) radiofrequency (RF) ablation laparoscopic liver resection stem cell intravascular RF ablation endobiliary RF ablation
High-intensity focused ultrasound tumor ablation: Review of ten years of clinical experience
Lian ZHANG, Zhi-Biao WANG
《医学前沿(英文)》 2010年 第4卷 第3期 页码 294-302 doi: 10.1007/s11684-010-0092-8
关键词: high-intensity focused ultrasound (HIFU) ultrasound imaging-guided HIFU (USgHIFU) magnetic resonance imaging-guided HIFU (MRgHIFU)
Jianpeng Liu, Xinhua Chen, Shusen Zheng
《医学前沿(英文)》 2021年 第15卷 第2期 页码 170-177 doi: 10.1007/s11684-020-0747-z
关键词: nanosecond pulsed electric fields (nsPEF) hepatocellular carcinoma (HCC) immune response recurrence metastasis
陈俐,巩水利,何恩光
《中国工程科学》 2020年 第22卷 第3期 页码 78-84 doi: 10.15302/J-SSCAE-2020.03.012
随着激光技术的发展,激光去除与连接技术深刻影响着制造业技术的发展,并以柔性、高效、高质的综合优势成为不可或缺的先进制造技术。在先进制造智能化发展的时代,激光技术、数字信息技术等的融合必将推动激光去除与连接技术的应用发展与创新。本文选取工业应用最广的激光焊接、激光切割、激光打孔、激光打标4 种激光去除与连接技术,概述了激光去除与连接技术的应用现状,分析了其在支撑先进制造发展过程中存在的问题。研究表明,激光去除与连接技术的发展应注重工艺基础和装备研究一体化的研究,解决激光加工单元部件、激光加工工艺、智能集成各环节的关键技术,强化工艺基础研究平台建设,关注技术创新和人才培养的多维度结合,以促进激光去除与连接技术从工艺应用开发到装备市场保障的生态链式的协同发展。
Temperature field simulation of laser homogenizing equipment
Juanjuan WANG, Yunshan WANG, Fudong ZHU
《机械工程前沿(英文)》 2009年 第4卷 第1期 页码 49-52 doi: 10.1007/s11465-009-0005-1
关键词: laser homogenizing technology laser scanning ring facula temperature field
“我国激光技术与应用2035 发展战略研究”项目综合组
《中国工程科学》 2020年 第22卷 第3期 页码 1-6 doi: 10.15302/J-SSCAE-2020.03.001
为促进激光技术及应用的发展,中国工程院于2018 年启动了“我国激光技术与应用2035 发展战略研究”重点咨询项目,本文是项目研究综合报告,文章简要分析了激光技术及在科研与产业中的工具性、引领性和颠覆性作用,分析了我国激光技术在前沿激光、制造加工、信息通信、医疗诊治等领域的科研和应用的发展现状,梳理了多个制约加速发展的问题,提出了我国激光技术及应用2035 年发展目标设想:强化顶层统筹谋划,引领我国激光技术与应用产业快速发展;加强基础研究,聚力突破产业化发展中的重大基础问题、共性技术基础和基础材料、器件;设立应用研发专项,打造多个新激光产业链;创新产业协同机制,完善激光产业创新生态;强化激光基础教育,加大对激光及光学学科人才培养力度等政策措施建议。
《机械工程前沿(英文)》 2022年 第17卷 第4期 doi: 10.1007/s11465-022-0703-5
关键词: laser beam welding parameter optimization metamodel multi-objective
Development of lunar regolith composite and structure via laser-assisted sintering
《机械工程前沿(英文)》 doi: 10.1007/s11465-021-0662-2
关键词: in situ manufacturing laser-assisted powder fusion process mechanical properties topological structure design
张群莉,王梁,梅雪松,姚建华
《中国工程科学》 2020年 第22卷 第3期 页码 71-77 doi: 10.15302/J-SSCAE-2020.03.010
激光表面改性技术利用高能量密度的激光束对零部件局部易损易耗区域进行快速处理,获得材料表面所需性能,进而大幅延长零部件使用寿命,已在航空航天、石油化工、能源、交通、冶金等领域获得应用。本文针对激光冲击强化、激光淬火、激光熔覆3 种典型的激光表面改性技术,梳理了相应技术特点及国内外应用现状,凝练我国相关技术领域面临的差距与问题,总结激光表面改性技术的重点发展方向:专用合金材料制备、多能场激光复合表面改性、面向现场的激光再制造、激光冲击强化控形控性、激光表面改性智能化、激光表面微结构化。从政府引导、国产化创新、产业链完善、质量评价标准体系、人才培养等方面提出发展建议,以期为我国激光表面改性技术发展提供参考借鉴。
Advances in polishing of internal structures on parts made by laser-based powder bed fusion
《机械工程前沿(英文)》 2023年 第18卷 第1期 doi: 10.1007/s11465-022-0724-0
关键词: laser-based powder bed fusion polishing internal structures surface quality surface features post process additive manufacturing
《机械工程前沿(英文)》 2022年 第17卷 第2期 doi: 10.1007/s11465-022-0675-5
关键词: ceramic parts trimming computer-aided laser manufacturing 3D vision reconfigurable laser processing system
Hybrid forming mechanism of patternless casting and laser cladding
Zhongde SHAN, Fuzhen SUN, Yang LIU
《机械工程前沿(英文)》 2019年 第14卷 第4期 页码 393-401 doi: 10.1007/s11465-019-0550-1
关键词: patternless casting laser cladding hybrid forming rapid tooling
邱海霞,李步洪,马辉,魏勋斌,杨思华,李阳,谭一舟,陈德福,赵洪友,曾晶,顾瑛
《中国工程科学》 2020年 第22卷 第3期 页码 14-20 doi: 10.15302/J-SSCAE-2020.03.003
激光诊疗技术在生命健康领域得到了越来越多的成功应用,成为现代医学精准诊疗的重要组成部分。本文针对激光技术医疗应用主题,重点从实际应用和产业链的视角出发,梳理我国激光技术在临床治疗、诊断和产业化方面的发展现状、前景趋势和存在问题。研究发现,尽管我国在激光治疗技术、医用激光诊疗设备及其产业发展方面均取得了长足进步,但整体而言,激光医疗技术的临床应用仍处于跟踪起步和同步发展阶段,原创性应用研究有所缺乏,医用激光设备的研发和产业化处于中低端,用于精准诊疗的超快激光器等关键技术和高端设备仍未打破国外垄断。研究建议,设立我国激光医学二级学科,加强国家级激光医疗科技创新平台建设,针对性开展激光医疗器械法规建设,出台相关政策扶持激光医疗器械产业发展,组织攻关医用激光诊疗设备关键核心技术。
标题 作者 时间 类型 操作
Laser ablation of block copolymers with hydrogen-bonded azobenzene derivatives
Jintang Huang, Youju Huang, Si Wu
期刊论文
Towards the optimization of management of hepatocellular carcinoma
Xi Feng, Madhava Pai, Malkhaz Mizandari, Tinatin Chikovani, Duncan Spalding, Long Jiao, Nagy Habib
期刊论文
High-intensity focused ultrasound tumor ablation: Review of ten years of clinical experience
Lian ZHANG, Zhi-Biao WANG
期刊论文
Immune response triggered by the ablation of hepatocellular carcinoma with nanosecond pulsed electric
Jianpeng Liu, Xinhua Chen, Shusen Zheng
期刊论文
Temperature field simulation of laser homogenizing equipment
Juanjuan WANG, Yunshan WANG, Fudong ZHU
期刊论文
Processing parameter optimization of fiber laser beam welding using an ensemble of metamodels and MOABC
期刊论文
zone-layered trimming method for ceramic core of aero-engine blade based on an advanced reconfigurable laser
期刊论文
Hybrid forming mechanism of patternless casting and laser cladding
Zhongde SHAN, Fuzhen SUN, Yang LIU
期刊论文